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The SURMOUNT-1 Trial (Mounjaro/Zepbound) In the landmark SURMOUNT-1 trial, participants taking the highest dose of tirzepatide (15 mg) lost an average of 22.5% of their body weight over 72 weeks

Transl Psychiatry 15 , 374 (2025)

J Biol Chem 278 : 4044240454 Bondy C, Werner H, Roberts Jr CT, LeRoith D (1992) Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I and II